An overview on therapeutic potential and various applications of microbial collagenases

Wamik Azmi, Shikha Chauhan, Manisha Gautam

Abstract


Collagen is the most widely distributed class of proteins in the human body. Monomers of collagen are constantly being synthesized and degraded throughout the development of a healthy individual to adulthood. The collagenase subfamily found in human matrix (metalloproteinases), are capable of hydrolyzing native collagen under physiological conditions. Collagenases are produced by specific cells involved in repairs and remodelling processes and plays important role in connective tissue metabolism. Present article focus on the major sources, properties and therapeutic aspects of microbial collagenases in their relation with various diseases and its applications in medical and food industry. Collagenolytic enzymes are highly specific for collagen and have been the focus of much practical interest with respect to cosmetic, medical and food based applications. The most common uses of these enzymes appear to be in medicine as they have been used to treat burns and ulcers, to eliminate scar tissue and play an important role in the successful transplantation of specific organs.


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H Neurath,(1984)Science, 224(4647), 350-357.

G K Pal, PV Suresh, (2016)RSC Advances,6, 33763-33780.

S P Kaur, W Azmi, (2013) Current Biotechnology, 2(1),17-22.

C J Krepel, C M Gohr, C E Edmiston, S G Farmer,(1991) The Journal of Infectious Diseases, 163(5),1148-1150.

C J Krepel, C M Gohr, A P Walker, S G Farmer, C E Edmiston, (1992) Journal of Clinical Microbiology, (9), 30,2330-4.

Jung CM, Matsushita O, Katayama S, Sakurai J, OkabeA,(1999) Journal of Bacteriology, 181(9), 2816-2822.

M MAwad, D M Ellemor, A E Bryant , O Matsushita , R L Boyd, D L Stevens , J JEmmins, J I Rood ,(2000) Microbial pathogenesis, 28(2), 107-117.

H Takeuchi, Y Shibano, K Morihara, J Fukushima, S Inami, B Keil, A M Gilles, S Kawamoto, K Okuda, (1992) Biochemical Journal, 281(3), 703-708.

S Miyoshi , Y Nitanda, K Fujii, K Kawahara , T Li, Y Maehara, T Ramamurthy, Y Takeda, S Shinoda, (2008) FEMS microbiology letters, 283(2), 176-181.

M A Houle, D Grenier, P Plamondon, KNakayama, (2003) FEMS Microbiology Letters, 221(2),181-5.

J A McGregor, D Lawellin, A Franco-Buff, J K Todd, E L Makowski, (1986) American Journal of Obstetrics and Gynaecology, 154(6), 302-309.

M Gautam, W Azmi, (2017) Advances in Biotechnology and Microbiology, 4(2). DOI 10.19080/AIMB.2017.04.555633.

H Kawahara, M Kusumoto, Obata H, (1993) Bioscience, Biotechnology and Biochemistry, 57(8),1372-1373.

A Baehaki, Sukamo, D Syah, S Setyahadi, M T Suhartono. (2014) Asian Journal of Chemistry, 26(10), 2861–2864.

A S Duarte, A C Esteves, A Correia, (2012) Portugal patent application

E Rochima, N Sekar, I D Buwono, E Afrianto, R I Pratama ,(2016) Aquatic Procedia, 7, 76-84.

HNagano, K A To, (1999) Bioscience, Biotechnology and Biochemistry, 63(7), 181–3.

L H Tran, H Nagano, (2002) Journal of Food Science: Food Microbiology and Safety, 67(3), 3-6.

L Liu, M Ma, Z Cai1, X Yang,W Wang, (2010) Food Technology and Biotechnology, 48(2), 151-60.

Q Wu, C Li, C Li, H Chen, L Shuliang, (2010) Applied Biochemistry and Biotechnology, 160, 129-39.

W Suphatharaprateep, B Cheirsilp, A Jongjareonrak, (2011) New Biotechnology, 28(6): 649-55.

M J Benito, M Rodrigueoz, F Nunez, M A Asensio, M E Bermudez, (2002) Applied Environmental Microbiology, 68(7), 3532-6.

J F C Tomee, H F Kauffman, A H Klimp, J G R de Monchy, G H Koeter, (1994)Journal of Allergy Clinical Immunology, 93(4), 768-78.

A Nordwig, WF Jann, (1968) European Journal of Biochemistry, 3(4), 519-29.

JW Rippon, (1968) Journal of Bacteriology, 95(1), 43-6.

HS Hamdy, (2008) Indian Journal of Biotechnology, 7(3), 333-40.

P J Park, S H Lee, H Byun, S H Kim, S K Kim, (2002) Scomber Japonicus Journal of Biochemistry and Molecular Biology, 35(6), 576-82.

J Gross, C M Lapiere,(1962) Proceedings of the National Academy of Sciences, 48(6), 1014-22.

J B Bjarnason, J W Fox, (1994) Pharmacology Therapeutics, 62(3), 325-72.

A Lecroisey, A M Gilles, A De Wolf, B Keil, (1987) Journal of Biological Chemistry, 262(16), 7546-51.

M C AWanderley, J M W D Neto, C A Lima, S I C Silverio, J L LFilho, J A C Teixeira, A L F Porto, (2016) Journal of Applied Biology and Biotechnology, 4(04), 001-10.

D Petrova, A Derekova, S Vlahov, (2006) Folia Microbiologica, 51(2), 93-8. (b)

Y G Mahmoud, S M Abu El-Souod, S M El-Shourbagy, A S M El-Badry, (2007) Annals of Microbiology, 57(1), 109–13.

R Jain, P C Jain, (2010) Indian Journal of Experimental Biology, 48(2), 174-8.

C A Lima, P M B Rodrigues, T S Porto, D Viana, J L Lima Filho, A L F Porto,M G Carneiro da Cunha, (2009) Biochemical Engineering Journal,; 43(3): 315–20.

C A Lima, J L LFilho, B BNeto, A Converti, M G Carneiro da Cunha, A L F Porto, (2011) Biotechnology and Bioprocess Engineering, 16, 549–60.

K Mookhtiar, S D Steinbrink, H E Van Wart,(1985) Biochemistry, 24, 6527-33.

G I Goldberg, S M Wilhelm, A Kronberger, E A Bauer, G A Grant, A Z Eisen, (1986) Journal of Biological Chemistry, 261(14): 6600-05.

A Lecroisey, BKeil, (1985) European Journal of Biochemistry, 152(1), 123-30.

K Dano, J Romer, B S Nielsen, (1999) APMIS.; 107(1-6), 120-27.

G Murphy, R M Hembry, (1992) Journal of Rheumatology, 19(32), 61-4.

Z S Galis, G K Sukhova, R Kranzhofer, S Clark, P Libby, (1995) Proceedings of the National Academy of Sciences USA, 92(2), 402-6.

R D Hautamaki, D K Kobayashi, R M Senior, S D Shapiro, (1997) Science, 277(5334), 2002-4.

Z Werb, T H Vu, J L Rinkenberger, L M Coussens, (1999) APMIS, 107(1-6), 11-18.

M D Bond, H E Van Wart, (1984) Biochemistry, 23(13), 3077-85.

P Roy, B Colas, P Durand, (1996) Comparative Biochemistry and Physiology, 115B (1), 87-95.

G P Stricklin, E A Bauer, J JJeffrey, A Z Eisen, (1977) Biochemistry, 16(8), 1607-15.

E D Harris, C A Vater, (1982) Methods in Enzymology, 82, 423-52.

Matsushita, K Yoshihara, S Katayanami, J Minami, AOkabe, (1994) Journal of Bacteriology, 176(1), 149-56.

A F Chambers, L A Matrisian, (1997) Journal of National Cancer Institute, 89(17), 1260-70.

S L Parsons, S A Watson, P D Brown, H M Collins, R J C Steele, (1997) British Journal of Surgery, 84(2), 160-6.

S Curran, G I Murray, (1999) Journal of Pathology, 189(3), 300-08.

H Nagase, J F Woessner, (1999) Journal of Biological Chemistry, 274(31), 21491-2.

J Koblinski, A Abraham, BF Sloane, (2000) Clinica Chimica Acta, 291(2), 113-35.

V Knauper, S Cowell, B Smith, C Lopez-Otin, M O’Shea, H Morris, L Zardi, G Murphy, (1997) Journal of Biological Chemistry, 272(12), 7608-16.

AR Mackay, M Ballin, M D Pelina, AR Farina, AM Nason, JL HartzlerL, UP Thorgeirsson, (1992) Invasion and Metastasis, 12(3-4), 168-84.

S W Mankaa, F Carafolib, R Vissea, D Bihanc, N Raynalc, R W Farndalec, G Murphyd, J JEnghilde, E Hohenesterb, H Nagasea, (2012) Proceedings ofthe National Academy of Sciences, USA, 109(31), 12461-6.

B Peterhofsky, (1982) Methods in Enzymology, 82, 453-71.

D E Woolley, D R Roberts, J M Evanson, (1975) Biochemical and Biophysical Research Communications, 66(2), 747-754.

K A Mookhtiar, H E Van Wart, (1992) Matrix Supplement, 1, 116-126.

I A Goshev, E Gousterova, P Vasileva-Tonkova, Nedkov, (2005) Proceedings of Biochemisry, 40, 1627-1631.

D H Petrova, S A Shishkov, S SVlahov, (2006) Journal of Basic Microbiology, 46(4), 275-285. (a)

M C AWanderley, J M W D Neto, J L LFilho, C A Lima, J A C Teixeira, A L F Porto, (2017) Brazilian Journal of Microbiology, 48, 13-24.

Eckhard U, Schonauer E, Ducka P, Briza P, Nuss D, Brandstetter H, (2009) Biological Chemistry, 390(1), 11-18.

M Okamoto, Y Yonejima, Y Tsujimoto, Y Suzuki, K Watanabe, (2001) Applied Microbiology and Biotechnology, 57(1-2), 103-108.

A Baehaki, M T Suhartono, Sukarno, D Syah, A B Sitanggang, S Setyahadi, F Meinhardt, (2012) African Journal of Microbiology Research, 6(10), 2373-2379.

J Mukherjee, N Webster, L E Llewellyn, (2009) PLoS One, 4(9), e7177.

C A Lima, A C V F Júnior, J L LFilho, A Converti, D V Marques, M G Carneiro-da-Cunha, A L F Porto, (2013) Biochemical Engineering Journal, 75, 64–71.

S P Kaur, W Azmi, (2013) Current Biotechnology, 2(1),10-16. (a)

N Nishi, O Matsushita, K Yuube, H Miyanaka, AOkabe, F Wada, (1998) Proceedings of the National Academy of Sciences, USA, 95(12), 7018-7023.

Matasushita, T Koide, R Kobayashi, K Nagata, Okabe A, (2001) Journal of Biological Chemistry, 276(12), 8761-8770.

R Gupta, Q Beg, P Lorenz, (2002) Applied Microbiology and Biotechnology, 59(1), 15-32.

A Dayanandan, J Kanagaraj, L Sounderraj, R Govindaraju, S G Rajkumar,(2003) Journal of Cleaner Production, 11: 533-536.

G Y Zhao, M Y Zhou, H L Zhao, X L Chen, B BXie, X Y Zhang, H L He, B C Zhou, Y Z Zhang, (2012) Food Chemistry,134(4), 1738-1744.

N S Demina, (2007) WO2009002208-A1 WORU000522 RU2355383-C2 RU123728 (2009).

A Dettmer, M A Z Ayub, M Gutterres, (2011) Brazilian Journal of Chemical Engineering, 28(3), 373–380.

A S Duarte, A Correia, A C Esteves, (2016) Critical Review in Microbiology. 42(1), 106-126.

H Alipour, A Raz, S Zakeri, N D Djadid ,(2016) Asian Pacific Journal of Tropical Biomedicine, 6(11),975-981.

M Cemazar, M Golzio, G Sersa, J M Escoffre, A Coer, S Vidic, J Teissie, (2012) Human Gene Therapy, 23(1),128-137.

M Kato, Y Hattori, M Kubo, Y Maitani, (2012) International Journal of Pharmaceutics, 423(2), 428-434.

C E Brinckerhoff, J L Rutter, U Benbow, (2000) Clinical Cancer Research, 6(12), 4823-4830.

Z Li, W F Ni, S M Gu, J Wang, (2012) International Journal of Radiology, 21(3), 246-248.

D Zhang, Y Zhang, Z Wang, X Zhang, M Sheng, (2015) International Journal of Clinical and Experimental Medicine, 8(1), 526-532.

M Meng, L Wang, S Mao, (2006) ChineseMedical Journal, 6, 41-48.

J Wang, S C Shan, B Yuchuan, (2004) Journal of Physical Medicine and Rehabilation, 26, 50-2.

Z Q Wu, L X Wei, J Li, Y Wang, D H Ni, P Yang, Y Zhang, (2009) European Journal of Radiology, 72(3), 499-504.

Z J Wang, M Y Zhu, X J Liu, X XZhang, D Y Zhang, J M Wei, (2016) Medicine, 95(25), 25-30.

R Clark, H Peter, (2013) Gewerbestrasse: Springer.

I Mandl, (1972) Collagenase. New York, NY: Gordon and Breach Science Publishers, 1-16.

A M Gilligan, C R Waycaster, R Bizier, B C Chu, M J Carter, C E Fife, (2017) Advances in Wound Care (New Rochelle), 6(4): 125-134.

C T Milne, A Ciccarelli, M A Lassy, (2012) Wounds, 24(11), 317-322.

S K McCallon, D Weir, J C Lantis, (2015) Journal of the American College of Clinical Wound Specialists, 6(1-2), 14-23.

J Party, V Blanchette, (2017) International Wound Journal, 14(2), 1-11.

M Brazzelli, M Cruickshank, E Tassie, P McNamee, C Robertson, AElders, C Fraser, R Hernandez, D Lawrie, C Ramsay, (2015) Health Technology Assessment, 19(90).

C Ball, D Izadi, L S Verjee, J Chan, J Nanchahal, (2016) BMC Musculoskeletal Disorders, 17,345-61.

I Degreef, (2016) Rheumatology Therapy, 3(1), 43–51.

M Martin-Ferrero, (2014) Journal of Hand Surgery European,; 39(8), 826-832.

C Engstrand,B Krevers, G Nylander, J Kvist, (2014) Journal of Hand Surgery American, 39(7), 1333-1343.

F Syed, A N Thomas, S Singh, V Kolluru, S G Emeigh Hart, A Bayat, (2012) PLoS One, 7(2),e31430.

M A Badalamente, L C Hurst, P Benhaim, B M Cohen, (2015) Journal of Hand Surgery American, 40(5), 975-983.

F Verstreken, I Degreef, A Decramer, K Libberecht, W Vanhove, A Datco, J Vanhaecke, D Clermont, J Duerinckx, (2016) Acta OrthopaedicaBelgica, 82(2), 405-412.

M A Badalamente, L C Hurst, (2007) Journal of Hand Surgery American,32(6), 767-774.

M A Badalamente, (2007) World intellectual property organisation patent WO, 2007100675 (A2).

G L Sabatino, J R B J Del Tito, P J Bassett, H A Tharia, A G Hitchcock, (2007) US patent ,20070224183.

L C Hurst, M A Badalamente, V R Hentz, (2009) New England Journal of Medicine, 361(10), 968-79.

M A Badalamente, E Wang, (2009) US patent 20090010918.

A J Watt, C M Curtin, V R Hentz, (2010) Journal of Hand Surgery American, (4), 534-539.

A Barbir, A J Michalek, (2010) Journal of Biomechanics, 43(6), 1067-1073.

F Sasso, G Gulino, R Falabella, (2003) Urologia Internationalis, 78(1), 1-9.

D Warwick, J M Arandes-Renu, G Pajardi, J Witthaut, L C Hurst, (2016) Journal of Plastic Surgery and Hand Surgery, 50(5), 251-61.

K M Crivello, H G Potter, E S Moon, S K Rancy, S W Wolfe, (2016) Journal of Hand Surgery (European), 41(6), 614-620.

A J Thurston. Dupuytren’s disease. (2003) The Journal of Bone and Joint Surgery British, 85(4), 469-477.

U Schwarzer, F Sommer, T Klotz M, Braun, B Reifenrath, U Engelmann, (2001) BJU International, 88(7), 727-730.

A Kadioglu, A Boyuk, Salabas E, (2015) European Urology, 68(5), 908-9.

L A Levine, A L Burnett, (2013) The Journal of Sexual Medicine, 10(1), 230-244.

M Gelbard, I Goldstein, W J G Hellstrom, C G McMahon, T Smith, J Tursi, N Jones, G J Kaufman, C CCarson, (2013) Journal of Urology, 190(1), 199-207.

S C Honig, (2014) Therapeutic Advances in Urology, 6(2), 47-53.

E J Traore, W Wang, F A Yafi, W J G Hellstrom, (2016) Therapeutic Advances in Urology, 8(3), 192-202.

G V Campion, T E Hardington, (1993) Oxford textbook of rheumatology. Oxford: Oxford University Press.

E Bauer, A Eisen, J Jeffrey, (1971) Journal of Clinical Investigation, 50(10), 2056-64.

S Abe, Y Nagai, (1973) Journal of Biochemistry, 73(4), 897-900.

Harris E, DiBona D, Drane S, (1969) Journal of Clinical Investigations, 48(11), 2104-2113.

E Harris,S Krane, (1974) New England Journal of Medicine, 291, 605-609.

T E Cawston, (2002) Medicine, 30(8), 27-31.

M P Vincenti, I M Clark, C E Brinkerhoff, (1991) Arthritis and Rheumatology, 37(8), 1115-1126.

Sabbah HN, Goldstein S, (1993) European Heart Journal, 14(suppl_C), 24-29.

D Fan, A Takawale, J Lee, Z Kassiri, (2012) Fibrogenesis and Tissue Repair, 5(1), 15-27.

S C Tyagi, L Matsubara, K T Weber, (1995) Clinical Biochemist, 26(3), 191-198.

J P M Cleutjens, J C Kandala, E Guarda, R V Guntaka, K T Weber, (1995) Journal of Molecular and Cellular Cardiology, 27(6): 1281-1292.

G Olivetti, J M Capasso, E H Sonnenblick, P Anversa, (1990) Circulation Research, 67(1), 23-34.

P Anversa, G Olivetti, J M Capasso, (1991) American Journal of Cardiology, 68, 7D-16D.

P Christner, A Fein, S Goldberg, M Lippmann, W Abrams, G Winbaum, (1985) American Review of Respiratory Disease, 131(5), 690-695.

M Bruce, L Poncz, J Klinger, R Stern, J Tomashefski, D Dearborn, (1989) American Review of Respiratory Diseases, 132(3), 529-535.

D Micheali, H HFudenberg, (1974) Immunology and Immnopathology, 3(2), 187-192.

R Foronjy, J D’Armiento, (2001) Respiratory Research, 2(6), 348-352.

D S Goodsell, (1999) Oncologist, 4(3), 263-4.

Y Itoh, (2006) IUBMB Life, 58(10), 589-96.

E I Deryugina, J P Quigley, (2006) Cancer Metastasis Review, 25(1), 9-34.

B K Pilcher, J A Dumin, B D Sudbeck, S M Krane, H G Welgus, W C Parks, (1997) Journal of Cell Biology, 137(6), 1445-57.

H J Park, H J Lee, H Y Min, H J Chung, M E Suh, H Y Park-Choo, C Kim, H J Kim, E K Seo,S K Lee, (2005) European Journal of Pharmacology, 527(1-3), 31-36.

E Nuti, T Tuccinardi, A Rossello, (2007) Current Pharmaceutical Design, 13(20), 2087-3100.

I K Demedts, G GBrusselle, K R Bracke, K Y Vermaelen, R A Pauwels, (2005) Current Opinion in Pharmacology, 5(3), 257-263.

P K Srivastava, S G Dastidar, A Ray, (2007) Expert Opinion on Investigational Drugs, 16(7), 1069-1078.

A M Pendas, J A Uria, M G Jimenez, M Balbin, JP Freije, C Lopez-Otin, (2000) Clinica Chimica Acta, 291(2), 137-155.

F Mannello, (2011) BMC Medicine, 9, 95-101.

S Thirkettle, J Decock, H Arnold, C J Pennington, D M Jaworski, D R Edwards, (2013) The Journal of Biological Chemistry, 288(23),16282-16294.

C Soria-Valles, A Gutierrez-Fernandez, M Guiu, B Mari, A Fueyo, RR Gomis, C Lopez-Otin, (2014) Oncogene, 33(23),3054-3063.

D Anandan, WcNMarmer, R L Dudley, (2007) Journal of Industrial Microbiology and Biotechnology, 34(5), 339-347.

T Kin, X Zhai, T B Murdoch, A Salam, J Shapiro, R Jonathan, T Lakey, (2007) American Journal of Transplantation, 7(5), 1233-1241.

A C Nag, M Cheng, (1981) Tissue and Cell, 13(3), 515-523.

Beltran A, Bonnet M, OualiA, (2006) Journal of Food Science, 56(6), 1497-1499.

A Gutierrez-Fernandez, M Inada, M Balbín, A Fueyo, A S Pitiot, A Astudillo, K Hirose, M Hirata, S D Shapiro, A Noël, Z Werb, S M Krane, C Lopez-Otin, XS Puente, (2007) FASEB Journal, 21(10), 2580-91.

V K Swarna, R Venba,B Madhan, N K ChandrababuS Sadulla, (2008) Dyes and Pigments, 76(2), 338-47.

J S Brand, T J Hefley, (1984) Cell separation methods and selected applications. Academic Press, New York, 3, 265-83.

V A Patel, A Logan, J C Watkinson, S Uz-Zaman, MC Sheppard, JD Ramsden, MC Eggo, (2003) American Journal of Physiology Endocrinology and Metabolism, 284(1),168-76.

GJ Marcus, (1984) Endocrine Research, 10(2), 151-62.

JL Ray,R Leach, J M Herbert, Benson M, (2001) Methods in Cell Science, 23(4), 185-8.

ZA Szabo, (2003) Brain Res Protoc, 10(3), 139-47.

L Ravanti, V M Kahari, (2000) International Journal of Molecular Medicine, 6(4), 391-407.

B Jin, H J Alter, Z C Zhang, J W Shih, J M Esteban, T Sun, Y S Yang, Q Qiu, X L Liu, L Yao, H W Wang, L F Cheng, (2005) Laboratory Investigations, 85(8), 992-1002.

A N Balamurugan, G Loganathan, T Anazawa, J JWilhelm, T Yuasa, D M Radosevich, K KPapas, D E R Sutherland, R C McCarthy, B J Hering, (2009) Xenotransplantation, 16, 545.

Galper S, Cohn E, Spiegel Y, Chet I, (1991) Journal of Nematology, 23(3), 269-274.

G N Cox, M Kusch, R S Edgar, (1981) Journal of Cell Biology, 90(1), 7-17.

J R ALeushner, N L Semple, J Pasternak, (1979) Biochimica and Biophysica Acta, 580(1), 166-174.

R J Winkfein, J Pasternak, T Mudry, L H Martin, (1985) Experimental Parasitology, 59(2), 197-203.

I B Kingston, (1991) Parasitic Nematodes Antigens, Membranes and Genes (ed. Kennedy MWTaylor and Francis, London, 66-83.

A F Bird, J Bird, (1991) The Structure of Nematodes. Academic Press Inc., 55.

I L Johnstone, (1994) BioEssays, 16(3), 171-178.

K Boutsika, M S Phillips, S A MacFarlane, D J F Brown, R C Holeva, V C Blok, (2004) Plant Pathology, 53(1), 110–116.

X Huang, M MFinetti-Sialer, A Ciancio, (2005) Phytopathology, 95(3), 262–268.

X Huang, N Zhao, K Zhang, (2004) Research in Microbiology, 155(10), 811-816.

K Zhu, H Zhu, H Qian, (2006) Process Biochemistry, 41(6), 1296–1302.

Q Chen, H Guoqing, W Jinling, (2007) Journal of Food Engineering, 80(2), 490-496.

V Venugopal, R Lakshmanan, S N Doke, D R Bongirwar, (2002) Food Biotechnology, 14(1-2), 21-77.

A Anwar, M Saleemuddin, (1997) Biotechnology and Applied Biochemistry, 25(1), 43-46.

I Zerdani, M A Faid, Malki, (2004) International Journal of Agriculture and Biology, 6(5), 758-761.

R Parenteau-Bareil, R Gauvin, F Berthod, (2010) Materials, 3(3), 1863-1887.

C Meena, S A Mengi, Deshpande SG, (1999) Proceedings of the Indian Academy of Science, 111(2), 319-29.

K Watanabe, (2004) Applied Microbiology and Biotechnology, 63(5), 520-526.

S D Khare, C J Krco, M MGriffiths, H S Luthra, C S David, (1995) Journal of Immunology, 155(7), 3653-3659.

L K Myers, B Tang, E F Rosloniec, J M Stuart, T M Chiang, A H Kang, (1998) Journal of Immunology, 161(7), 3589-3595.

G Ku, M Kronenberg, D J Peacock, P Tempst, M L Banquerigo, B S Braun, J R Reeve,E Brahn, (1993) European Journal of Immunology, 23(3), 591-592.

Y Tokudome, K Nakamura, M Kage, H Todo, K Sugibayashi, F Hashimoto, (2012) International Journal of Food Sciences and Nutrition, 63(6), 689-695.




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